top of page

This site was designed with the

website builder. Create your website today.Start Now

Create Your First Project

Start adding your projects to your portfolio. Click on "Manage Projects" to get started

.pro-gallery-wix-wrapper {display: block !important;} .pro-gallery-wix-wrapper .gallery-item-container {opacity: 1 !important; display: block !important;}

Protein and Lipid Metabolism

A series of illustrations and diagrams focusing on protein and lipid metabolism, including unfolded protein degradation, lipid droplet scission, and mitochondrial protein dynamics.

LD-cytoskeleton interaction. Lipid droplets are transported on cytoskeletal fibers (actin filaments or microtubules) by cytoskeletonassociated motor molecules (myosins, kinesins, and dyneins). In most cases the adaptors linking motors to the LD surface are unknown.

LD-cytoskeleton interaction. Lipid droplets are transported on cytoskeletal fibers (actin filaments or microtubules) by cytoskeletonassociated motor molecules (myosins, kinesins, and dyneins). In most cases the adaptors linking motors to the LD surface are unknown.

Molecular constituents of LD-mitochondria MCS. MIGA2 is the only LD-mitochondria tether that binds directly to both organelles.

Molecular constituents of LD-mitochondria MCS. MIGA2 is the only LD-mitochondria tether that binds directly to both organelles.

ER proteostasis at LD-ER MCS. Unfolded ER proteins are marked for degradation by ubiquitination. Ubiquitinated proteins are transferred from ER to LDs at LD-ER MCS. LDs containing ubiquitinated proteins bud from the ER and are delivered to vacuoles for degradation by microautophagy.

ER proteostasis at LD-ER MCS. Unfolded ER proteins are marked for degradation by ubiquitination. Ubiquitinated proteins are transferred from ER to LDs at LD-ER MCS. LDs containing ubiquitinated proteins bud from the ER and are delivered to vacuoles for degradation by microautophagy.

LD-Lysosome/Vacuole MCS. The four quadrants (I-IV) display the different types of LD-lysosome/vacuole MCS during microlipophagy (μLP, beige) and chaperone-mediated autophagy (CMA, pink).

LD-Lysosome/Vacuole MCS. The four quadrants (I-IV) display the different types of LD-lysosome/vacuole MCS during microlipophagy (μLP, beige) and chaperone-mediated autophagy (CMA, pink).

LD biogenesis at LD-ER MCS. TAG accumulates between leaflets of the ER bilayer during lens formation. Seipins, Nem1, and LDAF1 localize to and are required for LD-ER MCS formation at sites of LD biogenesis. Other LD biogenesis proteins including FITM2 and Pex30 are recruited to LD-ER MCS and LDAF1 is later transferred from MD-ER MCS to the surface of LDs during LD budding from the ER membrane. Finally, LDs are separated from ER and released to cytosol during LD scission.

LD biogenesis at LD-ER MCS. TAG accumulates between leaflets of the ER bilayer during lens formation. Seipins, Nem1, and LDAF1 localize to and are required for LD-ER MCS formation at sites of LD biogenesis. Other LD biogenesis proteins including FITM2 and Pex30 are recruited to LD-ER MCS and LDAF1 is later transferred from MD-ER MCS to the surface of LDs during LD budding from the ER membrane. Finally, LDs are separated from ER and released to cytosol during LD scission.

.pro-gallery-wix-wrapper {display: block !important;} .pro-gallery-wix-wrapper .gallery-item-container {opacity: 1 !important; display: block !important;}

bottom of page